Reverse the Resistance to PARP Inhibitors
نویسندگان
چکیده
منابع مشابه
Reverse the Resistance to PARP Inhibitors
One of the DNA repair machineries is activated by Poly (ADP-ribose) Polymerase (PARP) enzyme. Particularly, this enzyme is involved in repair of damages to single-strand DNA, thus decreasing the chances of generating double-strand breaks in the genome. Therefore, the concept to block PARP enzymes by PARP inhibitor (PARPi) was appreciated in cancer treatment. PARPi has been designed and tested f...
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The pharmacological inhibitors of poly(ADP-ribose) polymerase (PARP) family of proteins have shown promising results in preclinical studies and clinical trials as a monotherapy or in combination therapy for some cancers. Thus, usage of PARP-inhibitors (PARPi) in cancer therapy is bound to increase with time, but resistance of cancer cells to PARPi is also beginning to be observed. Here we revie...
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ژورنال
عنوان ژورنال: International Journal of Biological Sciences
سال: 2017
ISSN: 1449-2288
DOI: 10.7150/ijbs.17240